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Riportiamo l'abstract di uno studio appena pubblicato dal gruppo francese che sta studiando la mastocitosi: hanno analizzato oltre 1700 casi di mastocitosi infantile, dei quali nel 67% si è avuta una regressione.
Complimenti per lo studio e ... per la buona notizia.
Br J Dermatol. 2015 Feb 8. doi: 10.1111/bjd.13567.
Paediatric mastocytosis: a systematic review
of 1747 cases.
Méni C1, Bruneau J, Georgin-Lavialle S, Le Saché de Peufeilhoux
L, Damaj G, Hadj-Rabia S, Fraitag S, Dubreuil P, Hermine O, Bodemer C.
Author information
Abstract
Paediatric mastocytosis was previously considered to be a benign and spontaneously
regressing disease. However, this evolution is impossible to predict. To clarify
the characteristics and course of paediatric mastocytosis, we performed a
literature review of 1747 cases published between 1950 and April 2014. Lesions
occurred before the age of 2 years in 90% of cases, and presented as urticaria
pigmentosa (75% of cases), mastocytoma (20%) or diffuse cutaneous mastocytosis
(5%). The male-to-female ratio was 1·4. KIT D816V mutation was detected
in 34% of 215 tested patients. Clinical regression (complete or partial) occurred
in 67% of cases and stabilization in 27%. However, the outcome was fatal in
2·9% of patients.
© 2015 British Association of Dermatologists.
